-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, Ly94J1xifMy00K2IDOoVKKB/XFX8IDU9LFNe/3H5r+GaiUo55wI6X4D8mTLHl3OX EqPPauSMSOCvESuslkx2Vw== 0000889812-99-000475.txt : 19990212 0000889812-99-000475.hdr.sgml : 19990212 ACCESSION NUMBER: 0000889812-99-000475 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 19990211 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G SEC ACT: SEC FILE NUMBER: 005-41771 FILM NUMBER: 99529384 BUSINESS ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 BUSINESS PHONE: 6199319200 MAIL ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: RELIANCE FINANCIAL SERVICES CORP CENTRAL INDEX KEY: 0000083047 STANDARD INDUSTRIAL CLASSIFICATION: LIFE INSURANCE [6311] IRS NUMBER: 510113548 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: PARK AVE PLZ STREET 2: 55 E 52ND ST 29TH FL CITY: NEW YORK STATE: NY ZIP: 10055 BUSINESS PHONE: 2129091100 MAIL ADDRESS: STREET 1: PARK AVENUE PLAZA STREET 2: 55 EAST 52ND STREET CITY: NEW YORK STATE: NY ZIP: 10055 FORMER COMPANY: FORMER CONFORMED NAME: LEASCO FINANCIAL SERVICES CORP DATE OF NAME CHANGE: 19740414 SC 13G 1 STATEMENT OF BENEFICIAL OWNERSHIP UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* ISIS PHARMACEUTICALS, INC. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock, Par Value $.001 per share - -------------------------------------------------------------------------------- (Title of Class of Securities) 464330109 ------------------- (CUSIP Number) May 5, 1998 - -------------------------------------------------------------------------------- (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: /X/ Rule 13d-1(b) / / Rule 13d-1(c) / / Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP NO. 464330109 G Page 2 of 6 Pages --------- ---- ---- 1. NAME OF REPORTING PERSON S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Reliance Financial Services Corporation I.R.S. Employer Identification No.: 51-0113548 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware 5. SOLE VOTING POWER 1,607,500 (See Note 1) NUMBER OF SHARES 6. SHARED VOTING POWER BENEFICIALLY OWNED BY EACH REPORTING 7. SOLE DISPOSITIVE POWER PERSON WITH 1,607,500 (See Note 1) 8. SHARED DISPOSITIVE POWER 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,607,500 (See Note 1 ) 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 5.8% (See Note 1 ) 12. TYPE OF REPORTING PERSON* HC *SEE INSTRUCTION BEFORE FILLING OUT! Item 1(a) Name of Issuer: ISIS Pharmaceuticals, Inc. ................................................................................ Item 1(b) Address of Issuer's Principal Executive Offices: 2292 Faraday Avenue, Carlsbad, California 92008 ................................................................................ Item 2(a) Name of Person Filing: Reliance Financial Services Corporation ................................................................................ Item 2(b) Address of Principal Business Office or, if none, Residence: Park Avenue Plaza, 55 East 52nd Street, New York, NY 10055 ................................................................................ Item 2(c) Citizenship: Delaware ................................................................................ Item 2(d) Title of Class of Securities: Common Stock, Par Value $.001 ................................................................................ Item 2(e) CUSIP Number: 464330109 ................................................................................ Item 3 (g) [X ] Parent Holding Company, in accordance with ss.240.13d-1(b)(1)(ii)(G) Item 4. Ownership. (a) Amount Beneficially Owned As of December 3l, l998 1,607,500 (See Note 1) ................................................................................ (b) Percent of Class: 5.8% (See Note 1) ................................................................................ (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote 1,607,500 (See Note 1) ................................................................................ (ii) shared power to vote or to direct the vote -0- (See Note 1) ................................................................................ (iii) sole power to dispose or to direct the disposition of 1,607,500 (See Note 1) ................................................................................ (iv) shared power to dispose or to direct the disposition of -0- ................................................................................ Item 5. Ownership of Five Percent or Less of a Class. Not Applicable ................................................................................ Item 6. Ownership of More than Five Percent on Behalf of Another Person. Not Applicable ................................................................................ Item 7. Identification and Classification of the Subsidiary which Acquired the Security Being Reported on By the Parent Holding Company. Reliance Insurance Company ................................................................................ Item 8. Identification and Classification of Members of the Group. Not Applicable ................................................................................ Item 9. Notice of Dissolution of Group. Not Applicable ................................................................................ Item 10. Certification. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of such securities and were not acquired and are not held in connection with or as a participant in any transaction having such purposes or effect. SIGNATURE February 11, 1999 as of December 31, 1998 ............................................................. Date RELIANCE FINANCIAL SERVICES CORPORATION By:/s/ James E. Yacobucci James E. Yacobucci Senior Vice President-Investments Note 1. At December 31, 1998, Reliance Insurance Company ("RIC") beneficially owned 807,500 shares of Common Stock and Common Stock Purchase Warrants entitling RIC to purchase 800,000 shares of Common Stock at a price of $25.00 per share. The Securities beneficially owned by RIC (assuming exercise of the Warrants) total 1,607,500 shares of Common Stock and represent 5.8% of the Securities outstanding. -----END PRIVACY-ENHANCED MESSAGE-----